The song debuted at number 12 on the Billboard Hot 100, and reached number four in its thirteenth week, becoming their highest-charting single in the United States; it surpassed "Worth It", which peaked at number 12. "Work from Home" also became the first top-five single in the country by a girl group in ten years, following the September 2006 peak of "Buttons" by The Pussycat Dolls at number three. Among national airplay charts, the song topped both the Mainstream Top 40 and Rhythmic Songs. As of December 2016, the single has sold 1.4 million digital downloads in the United States. The song has achieved multi-platinum certifications in several countries, including quintuple platinum in Canada and the United States. Following the outbreak of the COVID-19 pandemic, the song received renewed attention as a result of the increasing adoption and prominence of remote working.
On the week of March 7, 2016, "Work from Home" debuted at number 12 on the Billboard Hot 100 with 88,000 downloads sold, 10 million United States streams and 20 million radio impressions in its first week, marking the group's highest debut and equaling its best rank for "Worth It", which rose to number 12 in August 2015, twenty-three weeks after it was released. The following week, the song fell four spots to number 16. It would then rise three spots to number 13 and rise one more spot, to match its debut position for the week dated April 9, 2016. The following week, the song would climb two spots to reach a peak at number 10, earning the group their first and only top 10 single in the United States. Subsequently, they became the first all-female group to chart in the top 10 since "When I Grow Up" by The Pussycat Dolls peaked at number nine in 2008. It recorded a 6-4 jump on the Digital Songs chart selling 89,000 copies, a 34 percent increase from the previous week. The song also saw an 8-5 jump on Streaming Songs with steams of 14.4 million, a rise of 20 percent and 22-17 leap on the Radio Songs chart, retaining a 49 million audience, a 22 percent increase from the previous week. 2b1af7f3a8